I Was Shocked How Effective Shockwave Therapy Can Be

By Madora Pennington

I have an old knee injury. You probably have one, too. 

Or maybe it’s your hip, ankle or elbow.  Something that flares up from time-to-time and makes you say in frustration, “This old thing. Again?”

Decades ago, I slipped. Wearing heels as I was climbing into an SUV in the rain, my kneecap came down on the running board, stretching out the tendon. My knee swelled to the size of a baseball. Tendons stretched like that do not snap into their old shape. I have been limping ever since.

There is no simple surgery for a patella alta (high kneecap) injury. Over the years, I tried physical therapy, knee braces, taping the kneecap in place, prolotherapy (sugar injections) and platelet-rich plasma injections (PRP therapy). 

All of those helped to some degree. But still my knee continued to bother me, often when I did activities that I love, like tennis and running. 

It became so annoying, I thought it was time to work on it again.

Healing Shocks That Reduce Pain

In looking around for new modalities, I found something I had never heard of: Extracorporeal Shockwave Therapy (ESWT).

ESWT is a noninvasive treatment that uses a device applied to the skin near injured areas that emits high-energy acoustic sound waves that promote healing and repair tissue. 

Shockwave therapy was originally developed to break up kidney stones without surgery. Once shattered into smaller sizes, kidney stone fragments pass out of the kidneys easier and exit the body with the urine. 

The treatment on kidney stones was successful, but there were concerns that the shockwaves were so intense they might damage nearby bones. It turns out the shocks actually stimulate new bone formation. Later investigations showed that shockwaves at a different dose could also stimulate cellular regeneration in soft tissue. 

In 2000, the FDA approved a shockwave device for chronic plantar fasciitis (pain in the soles of the feet). And in 2002, the FDA approved another device for the treatment of tennis elbow, a repetitive strain injury common to tennis players.

Like nearly all technology, today’s ESWT devices are smaller, cheaper and easier to operate effectively. Most protocols suggest several sessions separated by about a week. Unfortunately, they are usually not covered by insurance.

ESWT can be used on a wide variety of conditions that would normally send a patient to physical therapy, such as tendon injuries, slow-healing bones, arthritis, calcific tendonitis of the shoulder, and more. 

Shockwave therapy can encourage bone formation, new blood vessels, growth factors, healing in tendon cells, and collagen remodeling, while lowering inflammation and pain signaling.

Shocking My Knee 

Studies on ESWT for a kneecap injury such as mine showed mixed results and were not very promising. But that did not deter me. 

I was happy to try something besides an injection, especially something that could reawaken dormant healing processes. Having physical therapy along with ESWT was also recommended, so I did that, too.

Shockwave therapy sounds like it could be painful. A few times during my treatments, it was. The tech can turn down the machine if the zaps are too much. Because stronger pulses are more effective, I tried to endure them. 

The shocks were oddly pleasant, giving me a bit of an adrenaline rush and immediate relief. The tech did not isolate her treatment to just the joint. She used it around the neighboring tissue and muscles.

After my second treatment, to my utter delight, going up and down many flights of stairs was easy for my knee. It actually felt good. My kneecap held firmly in place, not snapping around as it can. 

This was a faster, more significant improvement than any treatment I have had in the past.

I purchased a package of shockwave treatments and had more sessions to use, but my knee felt like it didn’t need any more shocks. So I switched to having ESWT on overworked areas that have helped my body compensate for the deficiencies in my knee. The overused muscles in my pelvis and neighboring hamstring helped keep me balanced as I unconsciously favored the injured knee.

The shockwaves flowing through my back and glute muscles were intense, but just as soothing as they were on my knee. I could feel them all the way through to my hip joint. The treatment lifted feelings of stress that I was not aware of, perhaps by allowing more blood flow around the nerves caught under all my musculoskeletal stress. 

This other-side treatment accelerated my physical therapy progress. In fact, my physical therapist’s assessment was that the knee itself was in good shape — it was the old compensatory muscle patterns that were causing me pain, like the shortened thigh muscle pulling the kneecap and causing discomfort. 

Those other modalities I pursued in the past may have been effective, but I never had the full course of physical therapy the injury needed until now. Perhaps this is why the studies I read recommend physical therapy in addition to ESWT in order to get the best result. 

Time will tell if my old knee injury and the package of dysfunction surrounding it can be resolved. I am optimistic. My tennis has never been better, as formerly tight, overworked muscles are free to support my swings. Running is not bothering my knee at all. 

I would try ESWT again on other unhappy joints and tissue in the future.

‘Hyperactive’ Stem Cells May Cause Spinal Stenosis

By Pat Anson

Stem cells are often touted for their ability to reduce pain, restore damaged tissues and joints, and even treat cancer.

But researchers at Weill Cornell Medicine and Hospital for Special Surgery have found that when a certain type of stem cell becomes hyperactive in the lower spine, it can lead to lumbar spinal stenosis – a painful back condition that affects over 100 million people worldwide.

These specialized stem cells help generate and restore tendon and ligament cells – normally a good thing –  but in the lower spine they can grow too rapidly, pressing against nerves in the spinal canal, causing pain, numbness and difficulty walking.

“Given that this cell appears to be the ultimate origin of all tendon and ligament cells, defects in this cell are likely at the heart of a wide range of tendon and ligament disorders,” said Matthew Greenblatt, MD, Associate Professor of Pathology and Laboratory Medicine at Weill Cornell and co-author of a study published in the journal Cell.

Greenblatt and his colleagues first identified the stem cell in mice and then looked for it in humans, finding it in kneecaps, Achilles tendons and spines.

“Everywhere we looked, we found this cell,” said Greenblatt. “So, we think this is the universal stem cell for tendons and ligaments throughout the body.”

MRI image of spinal stenosis with two arrows that show narrowing of the spinal canal. (Credit: Dr. Sravisht Iyer)

The researchers found unusually high stem cell numbers in ligaments taken from people with spinal stenosis. When these stenosis-derived cells were transplanted into mice, they produced more tendon cells than healthy stem cells did. The cells showed higher levels of calcium signaling than their healthy counterparts, a sign they are growing too quickly. 

“Though spinal stenosis is a complex condition, this really showed us that these cells are contributing to the pathology,” said Greenblatt.

The good news here is that once you identify the problem, you can start looking for solutions.

Researchers think a class of drugs currently used to manage high blood pressure -- calcium channel blockers – could be repurposed to treat spinal stenosis by reducing calcium signals and slowing the growth of the specialized stem cells. Clinical studies will be needed to explore that theory.

“This is probably the first work that's shown a potential therapeutic target for one of the most common spine conditions in the world,” said co-author Stravisht Iyer, MD, an Associate Professor of Orthopedics at Weill Cornell and a spine surgeon at Hospital for Special Surgery. “The findings are exciting for their potential to change the way we deliver spinal care.

“Identifying these specialized stem cells unlocks a new area of research that allows us to address this disease much more mechanistically, rather than just waiting until a patient’s condition worsens and requires surgery to relieve the nerve compression.”

Spinal stenosis is currently treated with painkillers, physical therapy and steroid shots. If those methods don’t provide enough relief, surgery can be used to remove bone and tissue pressing on spinal nerves or “spacers” can be inserted to relieve pressure on the spine.

In addition to stenosis, researchers hope to explore the role that specialized stem cells play in other conditions, such as Marfan syndrome, a genetic disorder that affects the body’s connective tissues.

The findings could also lead to new treatments for tendons and ligaments that heal poorly after injuries, including rotator cuff tears, Achilles tendon injuries, ligament reconstruction and chronic tendon degeneration.